Capitainer B Vanadate
Capitainer qDBS is CE-marked and registered as an IVD product according to the 98/97EC In vitro Diagnostic Medical Device Directive and registered with the US FDA as a Device Class 1. Product availability may vary from country to country and is subject to varying regulatory requirements. Please contact your local sales representative for availability.
A better standard for PEth analysis
patent pending PCT/EP2021/068386
The Capitainer B – Vanadate device is based on our proprietary technology integrating the phospholipase D (PLD) inhibitor sodium metavanadate (NaVO3) in the DBS paper disc. It is developed for accurate analysis of Phosphatidylethanol (PEth).
PEth is found in red blood cells and is an abnormal phospholipid that is formed in the presence of ethanol. It is formed via a transphosphatidylation reaction of phospholipase D (PLD). PEth accumulates with frequent alcohol consumption and is therefore a marker for long term alcohol use.
In blood that contains ethanol at sampling, PEth may continue to form after sampling  leading to falsely elevated concentrations. A well-known problem in venous blood samples. Formation of PEth can be stopped through inhibiting the PLD activity. Sodium metavanadate (NaVO3) is an effective PLD inhibitor that stops formation of PEth.
Accurate analysis of PEth
Capitainer B- Vanadate has the same design, accuracy, and user friendliness as Capitainer qDBS. However, the DBS disc collecting 10 ul of blood contains NaVO3ensuring that no PEth is formed post sampling. Capitainer B Vanadate is the only volumetric microsampling device scientifically shown to enable accurate PEth measurement .
We recommend reading the full publication of Beck et al.  for more details regarding the advantages with Capitainer B Vanadate in PEth analysis.
- Schröck A, Henzi A, Bütikofer P, König S, Weinmann W. Determination of the formation rate of phosphatidylethanol by phospholipase D (PLD) in blood and test of two selective PLD inhibitors. Alcohol. 2018 Dec;73:1-7. doi: 10.1016/j.alcohol.2018.03.003. Epub 2018 Mar 20. PMID: 30103144.
- Beck, O., Mellring, M., Löwbeer, C. et al. Measurement of the alcohol biomarker phosphatidylethanol (PEth) in dried blood spots and venous blood—importance of inhibition of post-sampling formation from ethanol. Anal Bioanal Chem 413, 5601–5606 (2021). https://doi.org/10.1007/s00216-021-03211-z
Dimensions: 78 x 43 x 3 mm
Sample volume: 2 x 10 ul
DBS paper: Ahlstrom grade 222
>80% of the device is paper based
<1,7 grams of plastics per device
Better than 0.5 μl as one Standard
Deviation (SD), (CV <5%)
Rate of over- or under-sampling
(with a deviation >3 SD) <0.1%
+15°C to +35°C
Relative humidity range:
15% to 90%
25% to 55%
The Card must be used within 30 minutes from opening the package
Collected qDBS samples can be stored at room temperature.
The stability of individual analytes in DBS samples should be validated by the responsible laboratory. In general, stability increases with lower temperature and lower humidity. qDBS discs can be stored in the freezer to extend stability. Please refer to the extensive literature for traditional DBS samples as guidance for individual analytes.
Dispose according to local regulations. Take care with blood stained materials and sharps.
Capitainer qDBS is CE-marked, registered as an IVD product according to the 98/97EC In vitro Diagnostic Medical Device Directive and registered with the US FDA as a Device Class 1.
Solna Torg 19
SE-171 45 Solna